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US 6,602,520 B1Granted
Method for producing quickly decomposable solid pharmaceutical preparations
AssigneeBayer Aktiengesellschaft
InventorsMarco Schroeder, Klaus-Jürgen Steffens
Life of this patent
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Abstract
Rapidly disintegrating preparations containing at least one active pharmaceutical ingredient and at least one excipient can be obtained by a simple process in which at least the predominant part of the complete composition of the ingredients for the preparation to be produced is granulated, the resulting granules and, where appropriate, the remainder of the ingredients are shaped in the presence of liquid virtually without pressure, and the resulting shaped articles are dried.
Claims7
A process for making a fast-dissolve medicament comprising the steps of:
- (a) preparing a combination comprising at least one active pharmaceutical ingredient and at least one excipient in the absence of a disintegrant, wherein at least the predominant part of the combination is granulated, to form a first mixture;
- (b) tabletting said mixture in the presence of 2.5 to 15% by weight of a liquid selected from the group consisting of water, ethanol, isopropanol and mixtures thereof at a pressure of up to 100 N/mm2 with a degree of compaction of 30 to 80%, to form a porous non-effervescent tablet;
- and
- (c) drying said porous non-effervescent tablet.
1 more element
Dependencies are inferred from the claim text.