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US 6,602,511 B2Granted
Microemulsions for use as vehicles for administration of active compounds
AssigneeAstraZeneca AB
InventorChristian von Corswant
Life of this patent
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Abstract
A non-toxic oil-in-water or bicontinous microemulsion used as a pharmaceutically acceptable vehicle for administration of one or more active compounds having a low solubility in water as well as a process for the preparation and the use thereof.
Claims22
A non-toxic oil-in-water or bicontinuous microemulsion as a vehicle for administration of at least one pharmaceutically active ingredient comprising:
- (a) a polar phase comprising water and at least one component for adjusting the polarity of the polar phase;
- (b) a surfactant film modifier in the amount of about 2.93% to about 13% by weight of the total emulsion, wherein the surfactant film modifier is a monohydric alcohol with 2-3 carbon atoms;
- (c) a non-polar phase comprising at least one pharmaceutically acceptable oil;
- and
- (d) a mixture of a hydrophilic surfactant and a hydrophobic surfactant up to 15% by weight of the total microemulsion, wherein the hydrophobic surfactant is selected from the group consisting of lecithin, sphingolipids and galacto lipids.
2 more elements
The microemulsion according to claim wherein 21, the polyethylene glycol is polyethylene glycol 400.
Dependencies are inferred from the claim text.