Method of immunization using a Group B Streptococcus type II and type III polysaccharide conjugate vaccine
AssigneeBaxter International Inc.
InventorsFrancis Michon, Catherine Uitz, Joseph Y. Tai
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Abstract
The process for depolymerizing Group B Types II and III streptococcal polysaccharide is disclosed which results in polysaccharide fragments having a reducing end suitable for conjugating to protein. Conjugate molecules, vaccines and their use to immunize mammals including humans are also disclosed.
Claims2
A method of immunizing a mammal against Group B Streptococcus (GBS) type II or type III infection comprising administering to a mammal an effective immunizing amount of a vaccine composition comprising a conjugate molecule comprising a Group B Streptococcus type II or type III polysaccharide fragment covalently bound to a protein, wherein the Group B Streptococcus type II or type LII polysaccharide fragment is obtained by a process comprising partial depolymerization by deamination, wherein the conjugate molecule has the structure
- wherein R1 is H and R2 is a sialylated heptasaccharide repeating-unit of formula
- wherein n is about 5 to about 50 for the type II GBS polysaccharide fragment and wherein R1 is a sialylated pentasaccharide repeating-unit of formula
- wherein n is about 5 to 50 and R2 is disaccharide NeuAc(2-3)β-D-Galp1- for the type III GBS polysaccharide fragment.
Dependencies are inferred from the claim text.