Methods and tests for producing and for inhibiting coronary artery vasospasms
AssigneeDimera Incorporated
InventorR. Kent Hermsmeyer
Life of this patent
Estimating the term…
Abstract
Methods for producing coronary vasospasms and for inhibiting coronary vasospasms are disclosed. Both in vivo and in vitro methods are disclosed. The methods are useful as tests for determining the ability of a chemical compound to inhibit or reduce coronary vasospasms.
Claims5
An in vivo method for determining the ability of a test chemical compound to inhibit or reduce coronary vasospasms comprising in sequence the steps of obtaining a coronary hyperreactive animal, exposing the vascular muscle cells of a coronary artery of said animal to said test chemical compound, then exposing said cells to a combination of serotonin and a thromboxane A2 mimetic, and observing the presence or absence of indicia of coronary artery vasospasm persisting for 5 minutes or more.
Dependencies are inferred from the claim text.