Signal recording of a receptor-effector-system by an extracellular planar potential-sensitive electrode
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenchaften e.V.
InventorsPeter Fromherz, Elisabeth Meyer, Bernhard Straub
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Abstract
The present invention relates to bioelectronic devices comprising living cells which are in operative contact with an extracellular planar potential-sensitive electrode, e.g. a field effect transistor. The cells comprise an ion channel/receptor system which is responsive to stimuli. Thus, the device is suitable as a bioelectronic sensor. The electrode may also have a capacitive stimulating spot, with which the electrical or functional state of the cell or its ion channel/receptor system may be affected.
Claims28
A bioelectronic device comprising
- (a) a cell which expresses an ion channel/receptor system wherein said ion channel/receptor system comprises an ion channel component that mediates an ion current through a cell membrane and a receptor component;
- and
- (b) an extracellular potential-sensitive electrode wherein the cell is in operative contact with said electrode,
- wherein the cell has been manipulated to overexpress said ion channel/receptor system.
A bioelectronic device comprising
- (a) a cell which expresses an ion channel/receptor system wherein said ion channel/receptor system comprises an ion channel component that mediates an ion current through a cell membrane and a receptor component;
- and
- (b) an extracellular planar potential-sensitive electrode wherein the cell is in operative contact with said electrode,
- wherein the ion channel is the potassium channel hSlo.
A bioelectronic device comprising
- (a) a cell which expresses an ion channel/receptor system wherein said ion channel/receptor system comprises an ion channel component that mediates an ion current through a cell membrane and a receptor component;
- and
- (b) an extracellular planar potential-sensitive electrode wherein the cell is in operative contact with said electrode,
- wherein the ion channel is the ionotropic glutamate receptor NMDA.
Dependencies are inferred from the claim text.