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US 6,599,886 B2Granted
Macrolide intermediates in the preparation of clarithromycin
AssigneeBiochemie
InventorsVictor Centellas, José Diago
Life of this patent
Estimating the term…
Abstract
The present invention relates to a process for the production of clarithromycin from an aqueous medium in anhydrous form and in the form of a hydrate.
Claims8
The compound having the formula
- which is a stable hydrate having a water content of 9 to 12% and an X-ray diffraction pattern of the following:
- d(A) I/I0 8.8 62 8.4 37 7.2 34 6.5 31 6.3 100 5.9 42.
The compound having the formula
- which is a stable hydrate having a water content of 5.5 to 8% and an X-ray diffraction pattern of the following:
- d(A) I/I0 8.2 30 7.5 100 4.7 35.
The compound having the formula
- having an X-ray diffraction pattern of the following:
- d(A) I/I0 9.5 66 7.4 100 4.84 41 4.80 37 4.7 37 4.6 45.
The compound having the formula
- and an X-ray diffraction pattern of the following:
- d(A) I/I0 9.5 66 7.4 100 4.84 41 4.80 37 4.7 37 4.6 45
- in anhydrous form.
Dependencies are inferred from the claim text.