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US 6,599,526 B2Granted
Pericardial anti-adhesion patch
AssigneeUniversity of North Texas Health Science Center at Fort Worth
InventorSlobodan Dan Dimitrijevich
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Abstract
The present invention is directed to an anti-adhesion patch, which is constructed using a tissue equivalent technique. The anti-adhesion patch comprises a collagenous material and at least one non-living cellular component. Also provided is a method for preventing tissue adhesions between organs and other tissues being operated upon during surgical procedures by utilizing the anti-adhesion patch disclosed herein.
Claims15
A method of constructing an anti-adhesion patch, comprising the steps of:
- (a) mixing human connective tissue cells with a collagenous material;
- (b) incubating the resulting mixture in a matrix organization medium to stimulate the cells to adapt to and organize the collagenous material into a mono-cellular tissue equivalent having desirable dimensions and mechanical properties;
- (c) treating the tissue equivalent to eliminate the cells;
- and
- (d) confirming the absence of viable cells in the tissue equivalent after the treatment, wherein said tissue equivalent may be used as an anti-adhesion patch.
2 more elements
Dependencies are inferred from the claim text.