Preparation of peroxide-oxidized, sulfonated, and phosphorylated cotton
AssigneesVirginia Commonwealth University, The United States of America as represented by the Department of Agriculture
InventorsKelman I. Cohen, Robert F. Diegelmann, Dorne Yager, Judson Vincent Edwards
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Abstract
The invention provides wound dressings and methods of their use, especially for the treatment of chronic, non-healing wounds. The wound dressings are composed of a support matrix, such as cotton cellulose, and an active agent associated with the support matrix. The active agent may be a protease inhibitor or a protease sequestrant, in particular an inhibitor or sequestrant of a neutrophil-derived cationic protease such as elastase.
Claims4
A method for sequestering elastase at a wound site, comprising the step of contacting said wound site with a dialdehyde gauze wound dressing.
A method for sequestering elastase at a wound site, comprising the step of contacting said wound site with a sulfonated gauze wound dressing.
A method for sequestering elastase at a wound site, comprising the step of contacting said wound site with a phosphorylated gauze wound dressing.
A method for sequestering elastase at a wound site, comprising the step of contacting said wound site with a cotton gauze wound dressing selected from the group consisting of a dialdehyde cotton, a sulfonated cotton, or a phosphorylated cotton.
Dependencies are inferred from the claim text.