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US 6,599,509 B2Granted
Compositions and methods comprising helicobacter antigens for treatment and prevention of inflammatory bowel disease
AssigneeMassachusetts Institute of Technology
InventorsJames J. Fox, Adrian Lee, Mark Whary, David Schauer
Life of this patent
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Abstract
The treatment of IBD in mammals, including humans, is described. More particularly, the present invention relates to compositions and methods for the treatment of IBD associated with Helicobacter or other bacterial infections in mammals, including humans, and to vaccine compositions and antibodies suitable for use in such treatment.
Claims25
A method for treating inflammatory bowel disease, comprising:
- a) providing:
- i) a host having symptoms of inflammatory bowel disease and ii) a composition comprising inactivated whole organisms or whole cell lysates of an organism selected from the group consisting of H. fenelliae, H. cinaedi, H. pullorum, H. rappini, H. muridarum, H. hepaticus, and H. bilis;
- b) orally administering to said host an effective amount of said composition so as to elicit an immune response, and ameliorate said symptoms of inflammatory bowel disease.
A method for preventing inflammatory bowel disease, comprising:
- a) providing:
- i) a host at risk for inflammatory bowel disease and ii) a composition comprising inactivated whole organisms or whole cell lysates of an organism selected from the group consisting of H. fenelliae, H. cinaedi, H. pullorum, H. rappini, H. muridarum, H. hepaticus, and H. bilis;
- and
- b) orally administering to said host an effective amount of said composition so as to elicit an immune response, and prevent said host from experiencing symptoms of inflammatory bowel disease.
1 more element
A method for treating inflammatory bowel disease, comprising:
- a) providing:
- i) a host having symptoms of inflammatory bowel disease and ii) a composition comprising an adjuvant and inactivated whole organisms or whole cell lysates of an organism selected from the group consisting of H. fenelliae, H. cinaedi, H. pullorum, H. rappini, H. muridarum, H. hepaticus, and H. bilis;
- and
- b) orally administering to said host an amount of said composition so as to elicit an immune response, and ameliorate said symptoms of inflammatory bowel disease.
1 more element
A method for preventing inflammatory bowel disease, comprising:
- a) providing:
- i) a host at risk for inflammatory bowel disease and ii) a composition comprising an adjuvant and inactivated whole organisms or whole cell lysates of an organism selected from the group consisting of H. fenelliae, H. cinaedi, H. pullorum, H. rappini, H. muridarum, H. hepaticus, and H. bilis;
- and
- b) orally administering to said host an effective amount of said composition so as to elicit an immune response, and prevent said host from experiencing symptoms of inflammatory bowel disease.
1 more element
A method for treating inflammatory bowel disease, comprising:
- a) providing:
- i) a host having symptoms of inflammatory bowel disease and ii) a composition comprising inactivated whole organisms or whole cell lysates of an organism selected from the group consisting of H. fenelliae, H. cinaedi, H. pullorum, H. rappini, H. muridarum, H. hepaticus, and H. bilis;
- and
- b) orally administering to said host an amount of said composition so as to elicit an immune response, and ameliorate said symptoms of inflammatory bowel disease wherein said symptoms comprise rectal prolapse.
1 more element
A method for treating inflammatory bowel disease, comprising:
- a) providing:
- i) a host having symptoms of inflammatory bowel disease and ii) a composition consisting of inactivated whole organisms or whole cell lysates of H. bilis, H. hepaticus, H. muridarum, H. rodentium, or H. trogontum, and;
- b) orally administering to said host an amount of said composition so as to elicit an immune response, and ameliorate said symptoms of inflammatory bowel disease.
A method for preventing inflammatory bowel disease, comprising:
- a) providing:
- i) a host at risk for inflammatory bowel disease and ii) a composition consisting of inactivated whole organisms or whole cell lysates of H. bilis, H. hepaticus, H. muridarum, H. rodentium, or H. trogontum, and;
- b) orally administering to said host an effective amount of said composition so as to elicit an immune response, and prevent said host from experiencing symptoms of inflammatory bowel disease.
A method for treating inflammatory bowel disease, comprising:
- a) providing:
- i) a host having symptoms of inflammatory bowel disease and ii) a composition a composition consisting of inactivated whole organisms or whole cell lysates of H. bilis, H. hepaticus, H. muridarum, H. rodentium, or H. trogontum, and;
- b) orally administering to said host an amount of said composition so as to elicit an immune response, and ameliorate said symptoms of inflammatory bowel disease wherein the symptoms comprise rectal prolapse.
A method for preventing inflammatory bowel disease, comprising:
- a) providing:
- i) a host at risk for inflammatory bowel disease and ii) a composition consisting of an adjuvant and inactivated whole organisms or whole cell lysates of H. bilis, H. hepaticus, H. muridarum, H. rodentium, or H. trogontum;
- and
- b) orally administering to said host an amount of said composition so as to elicit an immune response, and ameliorate said symptoms of inflammatory bowel disease wherein said symptoms comprise rectal prolapse.
1 more element
Dependencies are inferred from the claim text.