Papilloma virus-like particles, fusion proteins as well as processes for their production
AssigneeLoyola University of Chicago
InventorsLutz Gissmann, Jian Zhou, Martin Muller, Jeanette Painstil
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Abstract
The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Claims12
A vaccine comprising a papillomavirus virus-like particle (VLP) consisting of a truncated papillomavirus L1 protein, said truncated L1 protein consisting of an amino acid sequence having one or more carboxy terminal amino acid residues deleted from a full length L1 amino acid sequence, said papillomavirus L1 protein derived from a viral strain selected from the group consisting of BPV, HPV 6, HPV 11, HPV 16, HPV 18, HPV 33, HPV 35 and HPV 45, and a pharmaceutically acceptable carrier.
A vaccine comprising a papillomavirus virus-like particle (VLP) consisting of a truncated papillomavirus L1 protein and amino acid residues from a second protein, said truncated L1 protein consisting of an amino acid sequence having one or more carboxy terminal amino acid residues deleted from a full length L1 amino acid sequence, said papillomavirus L1 protein derived from a viral strain selected from the group consisting of BPV, HPV 6, REV 11, HPV 16, HPV 18, HPV 33, HPV 35 and HPV 45, said amino acid residues from the second protein replacing deleted amino acid residues in the truncated L1 protein, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.