D-form polypeptide that inhibits the interaction between LFA-1 and ICAM-1
AssigneeUniversity of Kansas
InventorsIwao Nozawa, Stephen Benedict, Marcia Chan, Teruna Siahaan, Scott Tibbetts
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Abstract
Methods and compositions useful in inhibiting integrin-associated diseases are provided. The compositions contain a polypeptide having one or more D-amino acids that inhibit integrin binding to its associated binding polypeptide. The compositions include retro-inverso polypeptides.
Claims5
A polypeptide that inhibits the interaction between LFA-1 and ICAM-1 consisting of a sequence as set forth in SEQ ID NO:6.
A composition comprising, a polypeptide derived from an LFA-1 binding site that inhibits the interaction between LFA-1 and ICAM-1, wherein the polypeptide has a sequence consisting of a sequence as set forth in SEQ ID NO:6.
A polypeptide that inhibits the interaction between LFA-1 and ICAM-1 consisting of a sequence as set forth in DLSYSLDDLR, wherein one or more of the amino acids are D-amino acids.
A composition comprising, a polypeptide derived from an LFA-1 binding site that inhibits the interaction between LFA-1 and ICAM-1, wherein the polypeptide has a sequence consisting of a sequence as set forth in DLSYSLDDLR, and wherein one or more of the amino acids are D-amino acids.
Dependencies are inferred from the claim text.