Uses of diterpenoid triepoxides as an anti-proliferative agent
AssigneesThe Board of Trustees of the Leland Stanford Junior University, Pharmagenesis, Inc.
InventorsGlenn D. Rosen, Edwin S. Lennox, John H. Musser
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Abstract
Combinations of diterpenoid triepoxides and anti-proliferative agents are used in a combination therapy to treat hyperproliferative disorders. Anti-proliferative agents of interest include agents active in killing tumor cells, as well as immunosuppressants, and a variety of other agents that reduce cellular proliferation in targeted tissues. Synergistic combinations provide for comparable or improved therapeutic effects, while lowering adverse side effects.
Claims4
A method of screening a tumor for benefit from a synergistic combination therapy comprising a vinca alkaloid and triptolide or a pharmaceutically acceptable ester thereof, the method comprising:
- obtaining a sample of cells from said tumor;
- determining if said cells express p21waf1/cip1 by detecting the presence of p21waf1/cip1 protein or mRNA;
- wherein tumors comprising cells that express said p21waf1/cip1 benefit from said synergistic combination therapy exposing said tumor cells to the synergistic combination and wherein said determining step compares expression of p21 waf1/cip1 in the absence and presence of said synergistic combination.
Dependencies are inferred from the claim text.