Heat stable colloidal iron oxides coated with reduced carbohydrates and carbohdrate derivatives
AssigneeAdvanced Magnetics, Inc.
InventorsErnest V. Groman, Kenneth G. Paul, Timothy B. Frigo, Howard Bengele, Jerome M. Lewis
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Abstract
Compositions, methods of making the compositions, and methods of using the compositions are provided for an enhanced magnetic resonance imaging agent and a hematinic agent, the agents comprising carboxyalkylated reduced polysaccharides coated ultrasmall superparamagnetic iron oxides. Methods of use of the carboxymethyl reduced dextran as a plasma extender are provided.
Claims26
A method of providing an iron oxide complex for administration to a mammalian subject, the method consisting of:
- producing a carboxyalkylated reduced polysaccharide iron oxide complex;
- and
- sterilizing the complex by autoclaving.
A method according to claim 11, wherein producing the carboxyalkylated reduced polysaccharide is achieved at a temperature of less than about 40° C.
A reduced carboxyalkylated polysaccharide iron oxide complex wherein the produced complex is stable at a temperature of about 121° C.
A method of providing a hematinic agent for treating a subject deficient in iron, consisting of the steps of:
- formulating a composition which is a carboxymethylated reduced ultrasmall iron oxide complex;
- and
- terminally sterilizing the composition by autoclaving.
A reduced carboxyalkylated polysaccharide iron oxide complex which is stable at a temperature of about 121° C., wherein a sodium salt of the complex does not contain an infrared absorption peak in the region of about 1650 cm−1 to about 1800 cm−1.
Dependencies are inferred from the claim text.