Method of diagnosing autoimmune disease
AssigneeFred Hutchinson Cancer Research Center
InventorMark Roth
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Abstract
The present invention relates to diagnostic applications. For autoimmune diseases more particularly, it is demonstrated herein that individuals with SLE, APLA, MCDS and PSS have antibodies that are specific for SR proteins. Thus, in particular aspects the present invention provides methods and compositions for diagnosing autoimmune disease using SR proteins and antibodies to detect the presence of SR protein-specific antibodies in an individual suspected of having autoimmune disease, wherein the presence of such antibodies is indicative of said individual suffering from autoimmune disease.
Claims16
A method of diagnosing an autoimmune disease in a mammal comprising:
- a) obtaining an antibody-containing sample from said mammal;
- b) contacting said sample with a composition comprising an isolated SR antigen;
- and
- c) detecting the presence of an SR antigen/anti-SR antibody complex;
- wherein the presence of an SR antigen/anti-SR antibody complex is diagnostic for an autoimmune disease.
Dependencies are inferred from the claim text.