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US 6,593,363 B1Granted
Diterpene derivatives and anti-inflammatory analgesic agents comprising the same
AssigneesSae Han Pharm Co., Ltd., Young Ger Suh
InventorsYoung Ger Suh, Young Hoon Choi, Hye Kyung Lee, Young Ho Kim, Hyoung Sup Park
Life of this patent
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Abstract
The present invention relates to diterpene derivatives prepared from the components which are extracted from Acanthopanax Koreanum and represented by Chemical Formula (1).
Claims7
A diterpene derivative represented by Chemical Formula 1:
- wherein R1 and R2 individually represent hydrogen or hydroxy, or they form a double bond in the cycle;
- R3 represents a vinyl, hydroxyethyl, methoxyethyl, acetyloxyethyl, methoxymethoxyethyl, methoxyethoxymethoxyethyl, methoxyiminoethyl or isoxazolinyl group;
- and R4 represents a hydroxymethyl, carboxyl, carboxymethyl, carboxyvinyl, carboxyethyl, carboxypropyl, carboxybutyl, carboxybutadienyl, carboxyallyl, carboxyhomoallyl, carbamoyl, methylcarbamoyl, hydroxycarbamoyl, carbazoyl, N-pipsylcarbamoylmethyl, N-pipsylcarbamoylethyl, N-pipsylcarbamoylbutadienyl or N-methanesulfonylcarbamoylethyl group, with the proviso that when R1 and R2 form a double bond in the cycle and R3 is vinyl, R4 is not carboxyl.
A method for treating inflammation, wherein the method comprises administering an effective amount of a diterpene derivative represented by Chemical Formula 1:
- wherein R1 and R2 individually represent hydrogen or hydroxy, or they form a double bond in the cycle;
- R3 represents a vinyl, hydroxyethyl, methoxyethyl, acetyloxyethyl, methoxymethoxyethyl, methoxyethoxymethoxyethyl, methoxyiminoethyl or isoxazolinyl group;
- and R4 represents a carboxyl, carboxymethyl, carboxyvinyl, carboxyethyl, carboxypropyl, carboxybutyl, carboxybutadienyl, carboxyallyl, carboxyhomoallyl, carbamoyl, methylcarbamoyl, hydroxycarbamoyl, carbazoyl, N-pipsylcarbamoylmethyl, N-pipsylcarbamoylethyl, N-pipsylcarbamoylbutadienyl or N-methanesulfonylcarbamoylethyl group, with the proviso that when R1 and R2 form a double bond in the cycle and R3 is vinyl, R4 is not carboxyl.
Dependencies are inferred from the claim text.