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US 6,592,901 B2Granted
Highly compressible ethylcellulose for tableting
AssigneeHercules Incorporated
InventorsThomas Durig, Ronald Haywood Hall, Richard A. Salzstein
Life of this patent
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Abstract
A pharmaceutical dosage form composition is composed of an ethylcellulose that has an ethoxyl range lower limit of 49.6%, an a viscosity of less than 53 cps and at least one active pharmaceutical ingredient. This dosage form is highly compressible and compactible forming harder tables or pellets with better release retardation than comparable prior art tablets.
Claims17
A pharmaceutical dosage form composition comprising
- a) ethylcellulose that has an ethoxyl range lower limit of 49.6%, a viscosity of less than 53 cps as measured on a Hercules Horizontal Capillary Viscometer at a temperature of 25° C. in a 5% solution, and a glass transition temperature (Tg) of less than 130° C., and
- b) at least one active pharmaceutical ingredient, wherein the dosage form is a tablet or pellet and has a compression strength greater than an analogous dosage form comprising ethylcellulose of similar form but has an ethoxyl range less than 49.6%.
Dependencies are inferred from the claim text.