Stabilized polyvinylpyrrolidone formulation
AssigneeBASF SE
InventorsVolker Bühler, Ulrich Filges, Tanja Schneider
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Abstract
Preparations in powder form comprising or consisting of soluble or insoluble polyvinylpyrrolidone and/or polyvinylpyrrolidone copolymers and suitable as aid for pharmaceutical formulations comprise in homogeneous dispersion very small amounts of heavy metals which are physiologically tolerated in these amounts, or very small amounts of peroxide-cleaving enzymes.
Claims17
A method for stabilizing a preparation in powder form comprising a soluble or insoluble polyvinylpyrrolidone homo- or copolymer or a mixture thereof, and suitable as aid for pharmaceutical formulations, which comprises
- providing an aqueous solution of the homo- or copolymer or the mixture thereof,
- adding to the aqueous solution peroxide-cleaving enzymes in an amount of from 0.1 to 20 ppm, and optionally heavy metals in amounts which are physiologically tolerated, and
- converting the homo- or polymer or the mixture thereof into the powder form by drying.
A method for stabilizing a preparation in powder form comprising a soluble or insoluble polyvinylpyrrolidone homo- or copolymer or a mixture thereof, and suitable as aid for pharmaceutical formulations, which comprises
- providing an aqueous solution of the homo- or copolymer or the mixture thereof,
- adding to the aqueous solution as a peroxide-cleaving enzyme catalase or peroxidase, and optionally heavy metals in amounts which are physiologically tolerated, and
- converting the homo- or polymer or the mixture thereof into the powder form by drying.
Dependencies are inferred from the claim text.