Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
AssigneeDynavax Technologies Corporation
InventorsEyal Raz, Mark Roman, Dino Dina
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Abstract
The invention relates to immunostimulatory oligonucleotide compositions. These oligonucleotides comprise an immunostimulatory octanucleotide sequence. These oligonucleotides can be administered in conjunction with an immunostimulatory peptide or antigen. Methods for modulating an immune response upon administration of the oligonucleotide are also disclosed. In addition, an in vitro screening method to identify oligonucleotides with immunostimulatory activity is provided.
Claims50
An immunomodulatory oligonucleotide comprising the sequence of SEQ ID NO:2.
An immunomodulatory composition comprising a polynucleotide comprising the sequence of SEQ ID NO:2, an antigen and an encapsulating agent, wherein the polynucleotide and the antigen are not conjugated to each other, and wherein the polynucleotide and the antigen are encapsulated within the encapsulating agent.
An immunomodulatory composition comprising (a) a polynucleotide comprising the sequence of SEQ ID NO:2;
- (b) an antigen;
- and (c) an adjuvant other than alum, wherein the polynucleotide and antigen are not conjugated to each other.
Dependencies are inferred from the claim text.