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US 6,587,718 B2Granted
Iontophoretic delivery to heart tissue
AssigneeSciMed Life Systems, Inc.
InventorDnyanesh Talpade
Life of this patent
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Abstract
A therapeutic agent is delivered to heart tissue in a body. The therapeutic agent is introduced to a first side of the heart tissue. An electrode is percutaneously located on a second side of the heart tissue. The electrode is energized to induce migration of the therapeutic agent into the heart tissue.
Claims11
An apparatus for delivering a therapeutic agent to heart tissue in a body the apparatus comprising:
- a first electrode instrument including:
- an intravascular catheter including an elongate shaft having a proximal end and a distal end;
- a first electrode coupled to the distal end of the elongate shaft of the intravascular catheter and insertable therewith to form the first electrode instrument wherein the elongate shaft is configured to be introduced and advanced through vasculature in the body and positioned in a heart chamber
- a second electrode instrument including a second electrode coupleable to a percutaneous needle operable to inject the therapeutic agent proximate to the heart tissue in the body;
- and
- an instrument interface coupleable to a power source and configured to supply a first potential to the first electrode and a second potential to the second electrode and the first and second potentials having a potential difference to induce migration of the therapeutic agent injected proximate to the heart tissue.
3 more elements
An apparatus for delivering a therapeutic agent to heart tissue in a body comprising:
- an intravascular catheter including an elongate member having a proximal end and a distal end;
- an intravascular electrode coupled to the distal end of the elongate member wherein the elongate member is configured to be introduced and advanced through vasculature in the body and positioned in a heart chamber;
- an extravascular electrode and the intravascular electrode and the extravascular electrode being coupleable to a power source;
- the extravascular electrode and the intravascular electrode being energizable to provide a potential difference between the extravascular electrode and the intravascular electrode to induce migration of the therapeutic agent;
- and
- a subcutaneous delivery patch containing the therapeutic agent.
3 more elements
In combination:
- a first instrument comprising:
- an extravascular therapeutic agent delivery device and a first electrode coupled to the extravascular therapeutic agent delivery device;
- and
- a second instrument comprising:
- an intravascular catheter including an elongated catheter shaft and a second electrode carried by the intravascular catheter and insertable into a body vessel with the intravascular catheter;
- an instrument interface coupleable to a power source and configured to supply a first potential to the first electrode of the first instrument and a second potential to the second electrode of the second instrument and the first and second potentials having a potential difference.
3 more elements
Dependencies are inferred from the claim text.