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US 6,586,625 B1Granted
Synthesis of 2-halobenzyl alkanoic acid
AssigneeBoulder Scientific Company
InventorsHamlin H. Barnes, Fredric R. Askham
Life of this patent
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Abstract
A method for synthesizing compounds of Formula I in which R is alkyl or aryl and X is any halogen is described.
Claims5
A method for synthesizing a compound of Formula I:
- which comprises:
- (i) providing a first reactant comprising salt of an acid of Formula II (R-COOH), wherein X is any halogen and R is C6 to C14 aryl or C6 to C20 alkyl in a non-interfering solvent;
- (ii) combining said step (i) first reactant with a second reactant comprising an alkali metal salt of a non-nucleophilic strong base and a non-interfering solvent which may be the same as or different from said first reaction mixture non-interfering solvent, wherein a step (ii) reaction mixture is provided;
- (iii) providing a solution of 2-halobenzyl halide in a non-interfering solvent which may be the same as or different from said step (i) or step (ii) non-interfering solvents;
- and
- (iv) adding said step (ii) first reaction mixture to said step (iii) 2-halobenzyl halide solution, wherein a step (iv) reaction mixture-containing a Formula I compound is produced.
3 more elements
A method which comprises:
- (i) providing a solution in a non-interfering solvent of an acid of Formula II R-COOH, wherein R is C1 to C10 alkyl;
- (ii) combining said step (i) solution with a solution of lithium diisopropyl amide in hexane, wherein a step (ii) reaction mixture is produced;
- (iii) combining said step (ii) reaction mixture with a solution of 2-chlorobenzyl chloride in hexane, wherein a step (iii) reaction mixture containing a Formula I compound is produced.
Dependencies are inferred from the claim text.