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US 6,586,623 B2Granted
Thiol-based NAALADase inhibitors
AssigneeGuilford Pharmaceuticals Inc.
InventorsTakashi Tsukamoto, Pavel Majer, Doris Stoermer, Barbara S. Slusher
Life of this patent
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Abstract
This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
Claims25
A compound of formula I
- or a pharmaceutically acceptable equivalent of said compound, wherein:
- R1, R2, R3, R4, R5, R6, R7 and R8 are independently hydrogen or C1-C3 alkyl;
- A1, A2, A3 and A4 are independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halo, nitro, phenyl, phenoxy, benzyl, benzyloxy or —COOH, or any adjacent two of A2, A3 and A4 form with the benzene ring a fused 5- or 6-membered carbocyclic or heterocyclic aromatic ring, said heterocyclic aromatic ring containing 1 or 2 oxygen, nitrogen and/or sulfur heteroatom(s).
Dependencies are inferred from the claim text.