Process for preparing(R)-4-cyano-3-hydroxybutyric acid ester
AssigneeSamsung Fine Chemicals Co., Ltd.
InventorsKyoung Rok Roh, Ho Sung Yu, Kyung Il Kim, Won Jang Lee, Dae Il Hwang
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Abstract
The present invention relates to a process for preparing (R)-4-cyano-3-hydroxybutyric acid ester derivatives and more particularly, to a process for preparing optically pure (R)-4-cyano-3-hydroxybutyric acid ester derivatives expressed by formula (1) in high yield by performing cyanation and sequential esterification of (S)-3,4-epoxybutyric acid salt as a starting material. In said formula, R represents linear or branched alkyl group with 1˜5 carbon atoms or benzyl group.
Claims5
A process for the preparation of (R)-4-cyano-3-hydroxybutyric acid ester expressed by the formula (1) which comprises:
- (A) cyanation of (S)-3,4-epoxybutyric acid salt expressed by the formula (2) to afford the compound expressed by the formula (3);
- and
- (B) esterification of the compound expressed by the formula (3),
- wherein M represents an alkali metal atom, an alkaline earth metal atom or an alkylammonium ion having 1˜4 carbon atoms;
- and R represents a linear or branched alkyl group having 1˜4 carbon atoms or a benzyl group.
Dependencies are inferred from the claim text.