Tricyclic amine derivatives
AssigneeDaiichi Pharmaceutical Co., Ltd.
InventorsMakoto Takemura, Hisashi Takahashi, Kenichi Kimura, Rie Miyauchi, Hitoshi Ohki, Katsuhiro Kawakami
Life of this patent
Estimating the term…
Abstract
The present invention relates to a compound having a tricyclic amine substituent which may have various substituents, the compound being represented by formula (I), a salt or hydrate thereof, and a hydrate of the salt and a drug containing them as an active ingredient. They exhibit excellent antimicrobial activity against Gram negative bacteria and Gram positive bacteria with a satisfactory fate and safety and are useful in the treatment of infectious diseases. wherein Q preferably represents the following partial structure which may have various substituents:
Claims8
A compound which is 1-(N-Benzyl-N-benzyloxycarbonyl)amino-4-benzyloxycarbonyl-4-azatricyclo[6.1.0.02,6]nonane or a salt or hydrate thereof, or a hydrate of the salt.
A compound which is 1-Amino-4-azatricyclo[6.1.0.02,6]nonane or a salt or hydrate thereof, or a hydrate of the salt.
A compound which is (1R,2R,6S)-1-(N-Benzyl-N-benzyloxycarbonyl)amino-4-p-anisoyl-4-azatricyclo[6.1.0.02,6]nonane or a salt or hydrate thereof, or a hydrate of the salt.
A compound which is (1R,2R,6S)-1-t-Butoxycarbonylamino-4-p-anisoyl-4-azatricyclo[6.1.0.02,6]nonane or a salt or hydrate thereof, or a hydrate of the salt.
A compound which is (1R,2R,6S)-1-t-Butoxycarbonylamino-4-p-methoxybenzyl-4-azatricyclo[6.1.0.02,6]nonane or a salt or hydrate thereof, or a hydrate of the salt.
A compound which is (1R,2R,6S)-1-t-Butoxycarbonylamino-4-azatricyclo[6.1.0.02,6]nonane or a salt or hydrate thereof, or a hydrate of the salt.
A compound which is (1R,2R,6S)-1-(N-Benzyl-N-benzyloxycarbonyl)amino-4-benzyloxycarbonyl-4 azatricyclo[6.1.0.02,6]nonane or a salt or hydrate thereof, or a hydrate of the salt.
A compound which is (1R,2R,6S)-1-Amino-4-azatricyclo[6.1.0.02,6]nonane, or a salt or hydrate thereof, or a hydrate of the salt.
Dependencies are inferred from the claim text.