α, α-dibromo-α-chloro-acetophenones as synthons

2,5-bis(2,2,2-trifluoroethoxy)-α,α-dibromo-α-chloro-acetophenone.

A process for the preparation of 2,5-bis(2,2,2-trifluoroethoxy)-α,α-dibromo-α-chloro acetophenone which comprises reacting 2,5-bis(2,2,2-trifluoroethoxy)-α-chloro acetophenone with bromine.

A process for the preparation of 2,5-bis(2,2,2-trifluoroethoxy)-N-(2-pyridylmethyl)-benzamide which comprises reacting 2,5-bis(2,2,2-trifluoroethoxy)-α,α-dibromo-α-chloro acetophenone with 2-(aminomethyl)pyridine.

A compound of the formula

• wherein R1 and R2 are independently hydrogen, C1-C6-alkyl, C3-C7-cycloalkyl, C1-C6-alkoxy, —N(C1-C6-alkyl)2, —S—C1-C6-alkyl, or phenyl, wherein the alkyl groups are unsubstituted or substituted by one or more halogen, hydroxy, —S—alkyl, —O—alkyl, carboxy, amido, or ester groups and when the R1 or R2 substituent is phenyl it is unsubstituted or substituted in the phenyl ring by halogen, C1-C6-alkyl, C3-C7-cycloalkyl, C1-C6-alkoxy, —N(C1-C6-alkyl)2, —S—C1-C6-alkyl, the alkyl groups of which are unsubstituted or substituted by one or more halogen, hydroxy, —S—alkyl, —O—alkyl, carboxy, amido, or ester groups;
• or R1 and R2 together with the phenyl ring carbons to which they are attached form a 5-7 member aliphatic, aromatic, heterocyclic, or heteroaromatic ring.