Protein rib, a cell surface protein that confers immunity to many strains of the group B Streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition
AssigneeGunnar Lindahl
InventorsGunnar Lindahl, Margaretha Stalhammar-Carlemalm, Lars Stenberg
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Abstract
This invention relates to a new protein, designated Rib, and subfragments, multiples or variants thereof, which confers protective immunity against infection with many group B streptococcal strains, in particular those of serotype III. The invention includes a procedure for purification of the protein, a procedure for preparation of highly specific antibodies, a reagent kit, a DNA sequence encoding the protein and a pharmaceutical composition comprising the protein or fragments or variants thereof.
Claims7
An isolated DNA comprising one or more repeats of SEQ ID NO:5, wherein the isolated DNA is not group B streptococcus chromosomal DNA.
An isolated DNA comprising one or more repeats encoding the polypeptide of SEQ ID NO:6.
An isolated DNA comprising a nucleotide sequence which encodes the polypeptide of SEQ ID NO:4.
A composition comprising, isolated DNA comprising
- a sequence selected from the group consisting of:
- i) one or more repeats of SEQ ID NO:5, and
- ii) a nucleotide sequence which encodes the polypeptide of SEQ ID NO:4,
- wherein said isolated DNA is not chromosomal DNA, and a suitable pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.