PR-domain containing nucleic acids, polypeptides, antibodies and methods
AssigneeThe Burnham Institute
InventorShi Huang
Life of this patent
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Abstract
The invention provides an isolated PR Family Member (PFM) nucleic acid molecule that contains a PFM PR domain nucleotide sequence, a PFM ZF domain nucleotide sequence, or a modification thereof. The invention also provides an isolated PFM nucleic acid molecule that contains a nucleotide sequence that encodes a PFM PR domain polypeptide, or that encodes a PFM ZF domain polypeptide, or that encodes an immunologically equivalent modification thereof. Also provided are isolated PFM oligonucleotides. The invention also provides methods for detecting a PFM nucleic acid molecule in a sample. Further provided is a method of modulating cell growth by expressing an encoded PFM polypeptide in the cell.
Claims36
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 15 but not, more than 300 contiguous nucleotides of SEQ ID NO:3, appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide consisting of a nucleotide sequence of at least but not more than 300 contiguous nucleotides of the antisense strand of SEQ ID NO:3, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 15 contiguous nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NOS:35 and 37, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide squence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 15 but not more than 300 contiguous nucleotides of SEQ ID NO:3.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 15 contiguous nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NOS:35 and 37.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 17 but not more than 250 contiguous nucleotides of SEQ ID NO:3, appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide consisting of a nucleotide sequence of at least 17 but not more than 250 contiguous nucleotides of the antisense strand of SEQ ID NO:3, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 17 contiguous nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NOS:35 and 37, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 17 but not more than 250 contiguous nucleotides of SEQ ID NO:3.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 17 but not more than 250 contiguous nucleotides of the antisense strand of SEQ ID NO:3.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 17 contiguous nucleotides of a nucleotide sequence selected from the group consisting of SEQ ID NOS:35 and 37.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 20 but not more than 200 contiguous nucleotides of SEQ ID NO:3, appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide consisting of a nucleotide sequence of at least 20 but not more than 200 contiguous nucleotides of the antisense strand of SEQ ID NO:3, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 20 contiguous nucleotides of SEQ ID NO:35, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 20 but not more than 200 contiguous nucleotides of SEQ ID NO:3.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 20 but not more than 200 contiguous nucleotides of the antisense strand of SEQ ID NO:3.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 20 contiguous nucleotides of SEQ ID NO:35.
An isolated PFM2 oligonucleotide, consisting of a nucleotides sequence of at least 25 but not more than 150 contiguous nucleotides of SEQ ID NO:3, appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide consisting of a nucleotide sequence of at least 25 but not more than 150 contiguous nucleotides of the antisense strand of SEQ ID NO:3, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 25 contiguous nucleotides of SEQ ID NO:35, said nucleotide sequence being appended at a 5′ or 3′ end to an unrelated nucleotide sequence.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 25 but not more than 150 contiguous nucleotides of SEQ ID NO:3.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 25 but not more than 150 contiguous nucleotides of the antisense strand of SEQ ID NO:3.
An isolated PFM2 oligonucleotide, consisting of a nucleotide sequence of at least 25 contiguous nucleotides of SEQ ID NO:35.
Dependencies are inferred from the claim text.