Modulators of the function of FAS receptors and other proteins
AssigneeYeda Research and Development Co. Ltd.
InventorsDavid Wallach, Mark Boldin, Tanya Goncharov, Yury V. Golstev
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Abstract
The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which binds to the p55 receptor. In addition, peptide inhibitors which interfere with the proteolytic activity of MORT-1-biding proteins having proteolytic activity are provided as well as a method of designing them.
Claims24
An isolated polypeptide that binds to MORT-1 protein, said polypeptide having a sequence comprising:
- (a) residues 1-182 of SEQ ID NO:5;
- (b) an analog of (a), differing therefrom by no more than ten changes in the amino acid sequence thereof, each said change being a substitution, deletion and/or insertion of a single amino acid, which analog binds to MORT-1 protein;
- (c) a fragment of (a) or (b), which fragment binds to MORT-1 protein;
- or
- (d) a derivative of (a), (b) or (c) by modification of a functional group which occurs as a side chain or an N- or C-terminal group of one or more amino acid residues thereof without changing one amino acid to another of the twenty commonly occurring natural amino acids, which derivative binds to MORT-1 protein.
A composition comprising a pharmaceutically acceptable carrier and a polypeptide that binds to MORT-1 protein, which polypeptide has a sequence comprising:
- (a) residues 1-182 of SEQ ID NO:5;
- (b) an analog of (a), differing therefrom by no more than ten changes in the amino acid sequence thereof, each said change being a substitution, deletion and/or insertion of a single amino acid, which analog binds to MORT-1 protein;
- (c) a fragment of (a) or (b), which fragment binds to MORT-1 protein;
- or
- (d) a derivative of (a), (b) or (c) by modification of a functional group which occurs as a side chain or an N- or C-terminal group of one or more amino acid residues thereof without changing one amino acid to another of the twenty commonly occurring natural amino acids, which derivative binds to MORT-1 protein.
Dependencies are inferred from the claim text.