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US 6,586,493 B1Granted
Polysaccharide-based hydrogels and pre-gel blends for the same
AssigneeArizona Board of Regents, Arizona State University
InventorsStephen P. Massia, Julie Trudel
Life of this patent
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Abstract
Disclosed are hyaluronate-containing hydrogels having angiogenic and vascularizing activity and pre-gel blends for preparing the hydrogels. The hydrogels contain a cross-linked matrix of a non-angiogenic hyaluronate and a derivatized polysaccharide material, in which cross-linking is effected by free-radical polymerization. Kits for preparing the hydrogels are also disclosed.
Claims14
A hydrogel having angiogenic and vascularizing activity prepared by a process which comprises:
- admixing a polysaccharide material at least partially substituted with an unsaturated, cross-linking moiety, and a non-angiogenic hyaluronic acid or a salt thereof, with a free-radical initiator in a solvent;
- and
- cross-linking the mixture to form the hydrogel having angiogenic and vascularizing activity.
Dependencies are inferred from the claim text.