Carbohydrazide-protease inhibitors
AssigneeSmithKline Beecham Corporation
InventorDennis Shinji Yamashita
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Abstract
The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
Claims14
A compound according to Formula V:
- wherein:
- R29 is
- R30 is —H or C1-6 alkyl;
- R31 is
- R32 is OCH2Ar, OCH2C1-6alkyl, aryl substituted C0-6alkyl heteroaryl substituted C0-6alkyl,4-imidazole methylene;
- 2-, 3-, or 4-pyridylmethyleneoxy;
- 4-pyridyl methylene, 2-pyridyl sulfonyl, 4-pyridyl, aryl C0-6alkyloxy, or heteroaryl substituted
- C0-6alkyloxy;
- R33 is C1-6alkyl, —CH2Ph, or —CH2CH2CO2R34;
- R34 is —H or C1-6alkyl;
- m is 0, 1, or 2;
- and pharmaceutically acceptable salts, hydrates and solvates thereof.
Dependencies are inferred from the claim text.