Heteroarotinoids containing urea or thiourea linker
AssigneesThe Board of Regents for Oklahoma State University, The Board of Regents for the University of Oklahoma
InventorsKenneth Darrell Berlin, Doris M. Benbrook, Eldon C. Nelson
Life of this patent
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Abstract
Compounds, known as heteroarotinoids, having varying abilities to inhibit growth of certain cancerous cells, induce normal cell differentiation, and induce apoptosis or death of cancerous cells, of the general formula: in which: Ar and Ar′ denote aryl substituents, and wherein at least one of said aryl substituents comprises an aromatic ring having at least one heteroatom in a fused, partially saturated ring; W denotes O or S; and Q denotes H or i-C3H7.
Claims27
A compound selected from those of the isomeric formulas:
- in which:
- G denotes H or CH3;
- R denotes H, CH3, or OCH3;
- Q denotes H or i-C3H7;
- W denotes O or S;
- and
- Z denotes NO2, CO2Et, CO2—n—C4H9 or SO2NH2.
A compound selected from those of the isomeric formulas:
- in which:
- G denotes H or CH3;
- R denotes H, CH3, or OCH3;
- Q denotes H or i-C3H7;
- W denotes O or S;
- and
- Z denotes NO2, CO2Et, CO2—n—C4H9 or SO2NH2.
A compound selected from those of the formula:
- in which:
- G denotes H, CH3, C(O)—CH3;
- R denotes H, CH3, or OCH3;
- W denotes O or S;
- Q denotes H or i-C3H7;
- and
- Z denotes NO2, CO2Et or CO2—n—C4H9.
Dependencies are inferred from the claim text.