US 6,586,457 B2Granted

Methods for inhibiting bone resorption

AssigneesMerck & Co., Inc., Merck Frosst Canada, Inc.

InventorsShun-Ichi Harada, Mohamed MacHwate, Gideon A. Rodan, Marc Labelle, Kathleen Metters, Robert N. Young

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Abstract

The present invention relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an EP4 receptor subtype antagonist.

Claims5

Dependent claims

A pharmaceutical composition comprising a therapeutically effective amount of an EP4 receptor subtype antagonist having an EC50 value of from about 0.1 nanoM to about 100 microM and a therapeutically effective amount of a bisphosphonate active.

Dependencies are inferred from the claim text.

Facts

Application: 09/817,424Filed 26 Mar 2001 · division
Priority: 15 Oct 1998
Published: US 2001/0012838 A19 Aug 2001
Granted: 1 Jul 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

G01N 33/88
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing:…
A61K 31/00
Medicinal preparations containing organic active ingredients
A61K 31/4196
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2,4-Triazoles
A61K 31/66
Medicinal preparations containing organic active ingredients: phosphorus compounds

Family

Application60/104,339Us provisional application · filed 15 Oct 1998
Application09/416,733Parent of this division · filed 13 Oct 1999
US 2001/0012838 A1Pre-grant publication · published 9 Aug 2001
US 6,414,006 B1Parent of this division
US 2002/0082287 A1Published application
US 6,586,457 B2This patent

From the US filing history. Foreign family members aren’t listed.

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