Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1

A method for prophylaxis or treatment of thrombosis, angina pectoris, cerebral infarction, myocardial infarction, pulmonary infarction, intra-atrial thrombus in atrial fibrillation, deep venous thrombus, disseminated intravascular coagulation syndrome, diabetic complications, restenosis and stroke, comprising administering to a mammal in need thereof an effective amount of a compound of Formula I:

• or a solvate, hydrate or a pharmaceutically acceptable salt thereof, wherein
• Y is —N—;
• Ar1 is an optionally substituted aryl or heteroaryl radical;
• Ar2 is an optionally substituted aryl or heteroaryl radical, wherein heteroaryl is selected from the group consisting of thienyl, benzothienyl, furyl, benzofuryl, thiazolyl, imidazolyl, isoxazolyl, pyrrolyl and pyrazolyl;
• m is 1;
• R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, and aryl or heteroaryl radical, all of which can be optionally substituted;
• and
• R2 is hydrogen, or an optionally substituted aryl or an optionally substituted heteroaryl radical;
• with the provisos that
• when R1 and R2 are hydrogen and Ar2 is an optionally substituted phenyl, then Ar1 is other than a phenyl group substituted with carboxyalkyl or an alkyl ester of carboxyalkyloxy;
• when R1 is hydrogen, and Ar2 and R2 are both a phenyl group, then Ar1 is other than a phenyl group substituted with carboxyalkyl;
• or
• when R1 and R2 are hydrogen and Ar2 is naphthyl, then Ar1 is other than a phenyl group substituted with carboxyalkyl.