Back to results
US 6,586,450 B2Granted
Phenethyl-thiourea compounds and use
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Taracad K. Ventatachalam
Life of this patent
Estimating the term…
Abstract
Novel phenylethyl-thiourea (PHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant, and multi-drug resistant strains of HIV.
Claims6
A method for inhibiting replication of multi-drug resistant or NNI resistant HIV comprising contacting said HIV with an inhibitory amount of a compound of formula I:
- wherein:
- n is 0 to 5;
- each R is an electron donating group;
- and
- R1 is substituted or unsubstituted pyridyl.
2 more elements
A method for inhibiting multi-drug resistant or NNI resistant HIV reverse transcriptase comprising contacting said HIV reverse transcriptase with an effective inhibitory amount of a compound of formula I:
- wherein:
- n is 0 to 5;
- each R is an electron donating group;
- and
- R1 is substituted or unsubstituted pyridyl.
2 more elements
Dependencies are inferred from the claim text.