Nicotine-containing, controlled release composition and method
AssigneeCambrex Charles City, Inc.
InventorJohn Allen Walling
Life of this patent
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AssigneeCambrex Charles City, Inc.
InventorJohn Allen Walling
Estimating the term…
A nicotine product having a nicotine release rate of not less than 70% over a 10 minute period as well as a process to produce such product Such product is produced by a process comprising the steps of (a) preparing an aqueous solution of an organic polyol; (b) mixing said aqueous solution of the organic polyol with a cation exchange resin selected from the group consisting of (i)—a methacrylic, weakly acidic type of resin containing carboxylic functional groups (ii)—polystyrene, strongly acidic type of resin containing sulfonic functional groups and (iii)—polystyrene, intermediate acidic type of resin containing phosphonic functional groups thereby forming a cation exchange resin mixture having some of its ion exchange sites partially blocked with said polyol; (c) admixing with said mixture of step (b) an aqueous solution of nicotine to form a nicotine-coated cation exchange resin admixture; and (d) removing water from said admixture. The nicotine composition having a nicotine release rate of not less than 70% over a 10 minute period results.
A method for preparing a nicotine composition having a nicotine release rate of not less than 70% over a ten minute period said method comprising (a) mixing an aqueous solution of an organic polyol with a cation exchange resin selected from the group consisting of (i)—a methacrylic, weakly acidic type of resin containing carboxylic functional groups (ii)—polystyrene, strongly acidic type of resin containing sulfonic functional groups and (iii)—polystyrene, intermediate acidic type of resin containing phosphonic functional groups thereby fonning a cation exchange resin mixture, said cation exchange resin having some of its ion exchange sites partially blocked with said polyol (b) admixing with said mixture of step (a) an aqueous solution of nicotine to form a nicotine-coated cation exchange resin admixture and (c) removing water from said admixture to produce said nicotine composition having a nicotine release rate of not less than 70% over a ten minute period.
The method according to claim wherein the ratio of cation exchange resin to nicotine is from about 2:1 to about 10:1.
Dependencies are inferred from the claim text.