β-carboline compounds

A compound of formula (II),

• the racemic-diastereomeric mixtures and optical isomers of said compound of formula (II), and pharmaceutically-acceptable salts thereof,
• wherein
• - - - represents an optional bond;
• J1 is N—R6;
• J2 is N—R1, O or S;
• X is N or N—R4, where X is N when both optional bonds are present and X is N—R4 when the optional bonds are not present;
• R1 is H, —(CH2)m—C(O)—(CH2)m—Z1, —(CH2)m—Z1, —(CH2)m—O—Z1 or (C0-C6)alkyl-C(O)—NH—(CH2)m—Z3;
• Z1 is an optionally substituted moiety selected from the group consisting of (C1-C12)alkyl, benzo[b]thiophene, phenyl, naphthyl, benzo[b]furanyl, thiophene, isoxazolyl, indolyl,
• R2 is (C1-C12)alkyl, (C0-C6)alkyl-C(O)—O—Z5, (C0-C6)alkyl-C(O)—NH—(CH2)m—Z3 or optionally substituted phenyl;
• Z5 is H, (C1-C12)alkyl or (CH2)m-aryl;
• Z3 is amino, (C1-C12)alkylamino, N,N-di-(C1-C12)alkylamino, —NH—C(O)—O—(CH2)m-phenyl, —NH—C(O)—O—(CH2)m—(C1-C6)alkyl or an optionally substituted moiety selected from the group consisting of phenyl, imidazolyl, pyridinyl and morpholinyl, piperidinyl, piperazinyl, pyrazolidinyl, furanyl and thiophene;
• R3 is H, (C1-C6)alkyl or optionally substituted phenyl;
• R4 is H, —C(═Y)—N(X1X2), C(═O)X2 or X2;
• Y is O or S;
• X2 is H or —(CH2)m—Y1—X3;
• X3 is H or an optionally substituted moiety selected from the group consisting of (C1-C12)alkyl, (C3-C8) cycloalkyl, (C1-C12)alkoxy, aryloxy, (C1-C12)alkylamino, N,N-di-(C1-C12)alkylamino, —CH-di-(C1-C12)alkoxy or phenyl;
• R5 and R8 are each independently selected from the group consisting of H, (C1-C12)alkyl, —(CH2)m—Y1—(CH2)m-phenyl-(X1)n, (C3-C12)cycloalkyl, (C3-C12)cycloalkenyl, —(CH2)m—S—(C1-C12)alkyl, (C1-C12)alkyl-S—S—(C1-C12)alkyl, —(CH2)m—(C1-C12)alkenyl and an optionally substituted moiety selected from the group consisting of phenyl, furanyl, thiophene, pyrrolyl, pyridinyl and
• provided that R5 and R8 are not both H at the same time;
• or R5 and R8 are taken together with the carbon atom to which they are attached to form
• spiro(C4-C12)cycloalkyl,
• Y1 is O, S, NH or a bond;
• A is a bond, —CO—, —C(O)O—, —C(O)NH—, —C(S)NH—, or —SO2—;
• B is a bond or —(CH2)q—, where q is an integer from 1 to 6;
• J3 is H, (C1-C6)alkyl, optionally substituted phenyl, optionally substituted heteroaryl or N(R9R10), where R9 and R10 are each independently selected from the group consisting of (C1-C6)alkyl, and optionally substituted phenyl, or R9 and R10 are taken together with the nitrogen to which they are attached to form a ring having 5 to 8 members including the nitrogen atom that R9 and R10 are attached to, where one of the ring members may optionally be an oxygen atom or NR11, where R11 is (C1-C6)alkyl, —C(O)—(C1-C6)alkyl, —C(O)—N(V1V2), —C(S)—N(V1V2), or optionally-substituted-phenyl-(C0-C6)alkyl-, where V1 and V2 are each independently H, (C1-C6)alkyl or optionally-substituted-phenyl-(C0-C6)alkyl;
• R6 is H or SO2-phenyl;
• R7 is H, Cl, F, Br, I, CF3, NO2, OH, SO2NH2, CN, N3, —OCF3, (C1-C12)alkoxy, —(CH2)m-phenyl-(X1)n, —NH—CO—(C1-C6)alkyl, —S—(C1-C12)alkyl, —S-phenyl-(X1)n, —O—(CH2)m-phenyl-(X1)n, —(CH2)m—C(O)—O—(C1-C6)alkyl, —(CH2)m—C(O)—(C1-C6)alkyl, —O—(CH2)m—NH2, —O—(CH2)m—NH—(C1-C6)alkyl, —O—(CH2)m—N-di-((C1-C6)alkyl) and —(C0-C12)alkyl-(X1)n;
• wherein an optionally substituted moiety or optionally substituted phenyl is optionally substituted by one or more substituents, each independently selected from the group consisting of Cl, F, Br, I, CF3, NO2, OH, SO2NH2, CN, N3, —OCF3, (C1-C12)alkoxy, —(CH2)m-phenyl-(X1)n, —NH—CO—(C1-C6)alkyl, —S—(C1-C12)alkyl, —S-phenyl-(X1)n, —O—(CH2)m-phenyl-(X1)n, —(CH2)m—C(O)—O—(C1-C6)alkyl, —(CH2)m—C(O)—(C1-C6)alkyl, —O—(CH2)m—NH2, —O—(CH2)m—NH—(C1-C6)alkyl, —O—(CH2)m—N-di-((C1-C6)alkyl) and —(C0-C12)alkyl-(X1)n;
• X1 for each occurrence is independently selected from the group consisting of hydrogen, Cl, F, Br, I, NO2, OH, —CF3, —OCF3, (C1-C12)alkyl, (C1-C12)alkoxy, —S—(C1-C6)alkyl, —(CH2)m-amino, —(CH2)m—NH—(C1-C6)alkyl, —(CH2)m—N-di-((C1-C6)alkyl), —(CH2)m-phenyl and —(CH2)m—NH—(C3-C6)cycloalkyl;
• m for each occurrence is independently 0 or an integer from 1 to 6;
• and
• n for each occurrence is independently an integer from 1 to 5.