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US 6,586,432 B2Granted
Neurokinin-1 receptor antagonists
AssigneeAstrazenela AB
InventorPeter Robert Bernstein
Life of this patent
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Abstract
Compounds having the general formula R1R2N—CH2CH2—CHAr1—CH2—NR3—CO—R4 (I) wherein R1, R2, R3, R4 and Ar are as defined in the specification, methods of making such compounds, methods of using such compounds for the treatment of diseases and pharmaceutical compositions comprising such compounds.
Claims8
A compound of the formula (I):
- R1R2N—CH2CH2—CHAr1—CH2—NR3—CO—R4 (I)
- wherein:
- R1 and R2 are joined to form an optionally substituted morpholino ring;
- Ar1 is phenyl mono- or di-substituted by halo;
- R3 is hydrogen or C1-6alkyl;
- R4 is optionally substituted naphth-1-yl;
- or
- pharmaceutically acceptable salts thereof.
5 more elements
Dependencies are inferred from the claim text.