Treatment of cerebrovascular disease
AssigneeMedicure International Inc.
InventorsWasimul Haque, Rajat Sethi
Life of this patent
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Abstract
A method of treating a cerebrovascular disease, particularly stroke, is described. A method of treating a cerebrovascular disease includes administering pyridoxal-5′-phosphate, pyridoxal, pyridoxine, pyridoxamine, 3-acylated analogues of pyridoxal, 3-acylated analogues of pyriodoxal-4,5-animal, pyridoxine phosphonate analogues, or pharmaceutical compositions thereof.
Claims12
A method of treating cerebral ischemia, cerebral hemorrhage, ischemic stroke, or hemorrhagic stroke in a mammal comprising administering a therapeutically effective amount of at least one compound of the formula
- wherein
- R1 is alkyl or alkenyl, in which alkyl or alkenyl can be interrupted by nitrogen, oxygen, or sulfur, and can be substituted at the terminal carbon by hydroxy, alkoxy, alkanoyloxy, alkanoyloxyaryl, alkoxyalkanoyl, alkoxycarbonyl, or dialkylcarbamoyloxy;
- alkoxy;
- dialkylamino;
- alkanoyloxy;
- alkanoyloxyaryl;
- alkoxyalkanoyl;
- alkoxycarbonyl;
- dialkylcarbamoyloxy;
- aryl, aryloxy, arylthio, or aralkyl,in which aryl can be substituted by alkyl, alkoxy, amino, hydroxy,halo, nitro, or alkanoyloxy;
- or
- a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of the formula
- wherein
- R1 is alkyl or alkenyl, in which alkyl or alkenyl can be interrupted by nitrogen, oxygen, or sulfur, and can be substituted at the terminal carbon by hydroxy, alkoxy, alkanoyloxy, alkanoyloxyaryl, alkoxyalkanoyl, alkoxycarbonyl, or dialkylcarbamoyloxy;
- alkoxy;
- dialkylamino;
- alkanoyloxy;
- alkanoyloxyaryl;
- alkoxyalkanoyl;
- alkoxycarbonyl;
- dialkylcarbamoyloxy;
- aryl, aryloxy, arylthio, or aralkyl,in which aryl can be substituted by alkyl, alkoxy, amino, hydroxy,halo, nitro, or alkanoyloxy;
- or
- a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.