Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies
AssigneeMerial Limited
InventorsJean-Christophe Audonnet, Annabelle Bouchardon, Michel Riviere
Life of this patent
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Abstract
Disclosed is an immunological or vaccine composition that includes at least one plasmid that contains and expresses in vivo in host canine cells a nucleic acid molecule that encodes an antigen of a canine pathogen, such as rabies G. The plasmid can include more than one nucleic acid molecule such that the plasmid can express more than one antigen. Also disclosed are methods for using and kits employing such compositions.
Claims20
A Canidae vaccine comprising an effective amount to elicit a protective immune response in a Canidae of a plasmid that contains and expresses in a Canidae host cell a nucleic acid molecule having a nucleic acid sequence encoding rabies G, and a pharmaceutically acceptable carrier.
A Canidae vaccine comprising an effective amount to elicit a protective immune response in a Canidae of a plasmid that contains and expresses in a Canidae host cell a nucleic acid molecule having a nucleic acid sequence encoding rabies G, and a pharmaceutically acceptable carrier, wherein the plasmid further contains and expresses in vivo in a Canidae host cell a nucleic acid molecule having a nucleic acid sequence from another Canidae pathogen.
A method for vaccinating a Canidae comprising administering to said Canidae an effective amount to confer protective immunity in the Canidae of a Canidae vaccine comprising an effective amount to elicit a protective immune response in a Canidae of a plasmid that contains and expresses in a Canidae host cell a nucleic acid molecule having a nucleic acid sequence encoding rabies G, and a pharmaceutically acceptable carrier.
A method of vaccinating a Canidae host comprising:
- administering to said Canidae a vaccine selected from the group consisting of a live whole vaccine, an inactivated whole vaccine, a subunit vaccine, and a recombinant vaccine;
- and thereafter, administering a Canidae vaccine comprising an effective amount to elicit a protective immune response in a Canidae of a plasmid that contains and expresses in a Canidae host cell a nucleic acid molecule having a nucleic acid sequence encoding rabies G, and a pharmaceutically acceptable carrier.
A kit comprising (i) a Canidae vaccine comprising an effective amount to elicit a protective immune response in a Canidae of a plasmid that contains and expresses in a Canidae host cell a nucleic acid molecule having a nucleic acid sequence encoding rabies G, and a pharmaceutically acceptable carrier, and (ii) a Canidae vaccine selected from the group consisting of a live whole vaccine, an inactivated whole vaccine, a subunit vaccine, and recombinant vaccine.
Dependencies are inferred from the claim text.