Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
AssigneeVical Incorporated
InventorCarl J. Wheeler
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Abstract
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
Claims36
A composition comprising an immunogen-encoding polynucleotide and an adjuvant composition comprising a (±)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(syn-9-tetradeceneyloxy)-1-propanaminium salt and one or more co-lipids.
A method for increasing the immune response to an immunogen in a vertebrate comprising administering into a tissue of said vertebrate an immunogenic composition comprising one or more immunogen-encoding polynucleotides and an adjuvant composition comprising a (±)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(syn-9-tetradeceneyloxy)-1-propanaminium salt, wherein said one or more polynucleotides are DNA, wherein said immunogen is expressed in the vertebrate in an amount sufficient to generate an immune response to said immunogen, and wherein said adjuvant composition increases said immune response.
Dependencies are inferred from the claim text.