Methods of enhancing functioning of the large intestine
Assignee1149336 Ontario Inc.
InventorDaniel J. Drucker
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Abstract
The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the large intestine. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of large intestine. Thus, the invention provides methods of proliferating the large intestine in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the large intestine, including inflammatory bowel diseases.
Claims16
A method for treating a subject suffering from Crohn's disease in which the functioning of the large intestine is impaired, comprising delivering to said subject an effective amount of a glucagon-like peptide-2 (GLP-2) receptor agonist to ameliorate said disease.
A method for treating a subject having, or at a risk of developing, a condition in which functioning of the large intestine is impaired,
- comprising delivering to the large intestine of said subject a GLP-2 receptor agonist in an amount effective to ameliorate said condition or the onset thereof, wherein said condition is selected the group consisting of pain, diarrhea, lethargy, weakness, dehydration, and a combination thereof,
- wherein functioning of the large intestine of said subject is enhanced by said method.
A method of treating a subject having, or at risk of developing, a condition ameliorated by enhanced growth of the large intestine,
- comprising delivering to the large intestine of the subject a GLP-2 receptor agonist in an amount effective to proliferate the tissue of the large intestine,
- wherein amelioration of said condition is measured by determining improvement of one or more symptoms selected from the group consisting of abdominal pain, diarrhea, rectal bleeding, weight gain, normalization of hemoglobin, normalization white blood cell count and sedimentation rate, appearance of the intestine on colonoscopy or sigmoidoscopy, intestine function as assessed radiologically by barium enema, and histology of the large intestine as assessed by specimen biopsy,
- wherein the tissue of the large intestine is proliferated by said method.
Dependencies are inferred from the claim text.