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US 6,586,398 B1Granted
Chemically modified novel erythropoietin stimulating protein compositions and methods
AssigneeAmgen Inc.
InventorsOlaf Kinstler, Colin Gegg, Aimee Freeman, Thomas Boone
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Abstract
The present invention broadly relates to the field of protein modification, and, more specifically, the attachment of water soluble polymers to novel erythropoietin stimulating protein (NESP).
Claims5
A substantially homogenous preparation of a chemically modified hyperglycosylated protein, Novel Erythropoietin Stimulating Protein (NESP), wherein said NESP is chemically modified with polyethylene glycol (PEGylated);
- and wherein said preparation is comprised of a mixed population of mono-PEGylated NESP and poly-PEGylated NESP and at least 95% PEGylated NESP molecules.
A pharmaceutical composition comprising:
- (a) a substantially homogenous preparation of a chemically modified hyperglycosylated protein, PEGylated NESP, said PEGylated NESP comprising a mixed population of mono-PEGylated NESP and poly-PEGylated NESP;
- (b) fewer than 5% non-PEGylated NESP molecules;
- and
- (c) a pharmaceutically acceptable diluent, adjuvant or carrier.
1 more element
Dependencies are inferred from the claim text.