Conjugates of antiviral proteins or peptides and virus or viral envelope glycoproteins
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorMichael R. Boyd
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Abstract
The present invention provides antiviral proteins, peptides and conjugates, as well as methods of obtaining these agents. The antiviral proteins, peptides and conjugates of the present invention can be used alone or in combination with other antiviral agents in compositions, such as pharmaceutical compositions, to inhibit the infectivity, replication and cytopathic effects of a virus, such as a retrovirus, in particular a human immunodeficiency virus, specifically HIV-1 or HIV-2, in the treatment or prevention of viral infection.
Claims5
A method of conjugating a virus with a cyanovirin, which method comprises contacting an isolated and purified virus with an isolated and purified antiviral protein or antiviral peptide comprising at least nine contiguous amino acids of SEQ ID NO:
- 2, wherein said at least nine contiguous amino acids of SEQ ID NO:
- 2 have antiviral activity, and wherein, upon contacting said isolated and purified virus with said isolated and purified antiviral protein or antiviral peptide, said isolated and purified antiviral protein or antiviral peptide binds to said isolated and purified virus, thereby forming a conjugate.
Dependencies are inferred from the claim text.