Method of ameliorating erectile dysfunction
AssigneeQueen's University at Kingston
InventorsJames D. Banting, Jeremy P. W. Heaton, Michael A. Adams
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Abstract
The mechanism of hypertension following acute NO synthase blockage is via endothelin-mediated vasoconstriction. Thus, NO appears to inhibit endothelin activity by blocking its expression and not as a chronic direct acting vasodilator. Administration of an endothelin antagonist to a patient in a ‘normal’ physiological state may result in specific regional vasodilation. This treatment finds utility in the treatment of erectile dysfunction.
Claims12
A method for ameliorating erectile dysfunction in a subject in which induction of erections by apomorphine is decreased or blocked, comprising administering to a said subject apomorphine and an agent which antagonizes actions of endothelin, or pharmaceutically acceptable salts thereof, in amounts sufficient so that erectile dysfunction is ameliorated.
Dependencies are inferred from the claim text.