Methods and materials relating to novel prothrombinase-like polypeptides and polynucleotides

An isolated polypeptide having prothrombinase activity comprising an amino acid sequence which is at least 99% identity to the amino acid sequence of SEQ ID NO:

• 9.
• Residues 181-217 Val Met Cys Asp Met Asp Tyr Arg Gly Gly Gly Trp Thr Val Ile Gln Lys Arg Ile Asp Gly Ile Ile Asp Phe Gln Arg Leu Trp Cys Asp Tyr Leu Asp Gly Phe Gly (designated as SEQ ID NO:
• 5),
• Residues 324-353 Cys Ser His Leu His Asn Lys Thr Gly Trp Trp Phe Asn Glu Cys Gly Leu Ala Asn Leu Asn Gly Ile His His Phe Ser Gly Lys Leu (designated as SEQ ID NO:
• 6),
• Residues 271-285 Phe Lys Met His Leu Gly Arg Tyr Ser Gly Asn Ala Gly Asp Ala (designated as SEQ ID NO:
• 7), and
• Residues 222-234 Glu Phe Trp Leu Gly Leu Lys Lys Ile Phe Tyr Ile Val (designated as SEQ ID NO:
• 8).