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US 6,586,389 B1Granted
Cubilin protein, DNA sequences encoding cubilin and uses thereof
AssigneeThe Administrators of the Tulane Educational Fund
InventorsPierre J. Verroust, Timothy G. Hammond
Life of this patent
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Abstract
The present invention provides novel renal receptors for ligands. Cubilin and megalin are representative examples of such renal receptors. Also provided are potential uses of these renal receptors for treating toxicity in various tissues and for detecting renal damage.
Claims5
An isolated and purified cubilin protein, where said protein has an amino acid sequence shown in SEQ ID No. 2, and where said protein is encoded by DNA selected from the group consisting of:
- (a) an isolated DNA which encodes a cubilin protein;
- and
- (b) an isolated DNA differing from the isolated DNA of (a) in codon sequence due to the degeneracy of the genetic code.
Dependencies are inferred from the claim text.