TAO protein kinases and methods of use therefor
AssigneeBoard of Regents, The University of Texas System
InventorsMelanie H. Cobb, Michele Hutchison, Zhu Chen, Kevin Scott Berman
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Abstract
Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
Claims14
An isolated polynucleotide comprising a nucleotide sequence provided in or complimentary to SEQ ID NO:1 or SEQ ID NO:3.
An isolated polynucleotide comprising a nucleotide sequence that encodes the polypeptide provided in SEQ ID NO:2, SEQ ID NO:4, or a variant thereof that is at least 90% identical to the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4, wherein the polynucleotide encodes a polypeptide capable of phosphorylating MEK3.
An isolated polynucleotide comprising a nucleotide sequence that encodes amino acids 1-416 of SEQ ID NO:2 or SEQ ID NO:4.
An isolated polynucleotide comprising a nucleotide sequence provided in or complimentary to SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, or SEQ ID NO:16, wherein the polynucleotide encodes a polypeptide capable of phosphorylating MEK3.
A polynucleotide according to 5, wherein the polynucleotide encodes a polypeptide that is a constitutively active variant of a TAO polypeptide.
An isolated polynucleotide comprising a nucleotide sequence that encodes a polypeptide that is at least 90% identical to the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:4, wherein the polynucleotide encodes a polypeptide that is a constitutively inactive variant of a TAO polypeptide.
Dependencies are inferred from the claim text.