ICE/CED-3 like protease designated FMH-1
AssigneeGenetics Institute, Inc.
InventorMichael R. Bowman
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Abstract
Polynucleotides encoding novel proteases designated “FMH-1” are disclosed. Host cells transformed with such polynucleotides and methods for making FMH-1 proteases are also disclosed. The invention also provides FMH-1 proteases and antibodies that react with them, along with pharmaceutical compositions comprising FMH-1 proteases or polynucleotides encoding FMH-1 proteases. Methods for treating conditions associated with excessive or insufficient apoptosis by administering such pharmaceutical compositions are also disclosed.
Claims9
An isolated polynucleotide comprising a nucleotide sequence selected from the group consisting of:
- a) the nucleotide sequence of SEQ ID NO:
- 1 from nucleotide 121 to nucleotide 1683;
- and
- b) a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:
- 2.
An isolated protein consisting of the amino acid sequence of SEQ ID NO:
- 2 having FMH-1 protease activity.
Dependencies are inferred from the claim text.