43239 a novel GPCR-like molecule and uses thereof
AssigneeMillennium Pharmaceuticals, Inc.
InventorsMaria Alexandra Glucksmann, Inmaculada Silos-Santiago
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Abstract
Novel GPCR-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length GPCR-like proteins, the invention further provides isolated GPCR-like fusion proteins, antigenic peptides, and anti-GPCR-like antibodies. The invention also provides GPCR-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GPCR-like gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
Claims8
An isolated nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1, the cDNA insert of the plasmids deposited with the ATCC as Accession Numbers PTA-2365, PTA-2166, or PTA-2366, or a complement thereof;
- and
- b) a nucleic acid molecule which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2, or an amino acid sequence encoded by the cDNA insert of the plasmids deposited with the ATCC as Accession Numbers PTA-2365, PTA-2166, or PTA-2366.
Dependencies are inferred from the claim text.