Back to results
US 6,586,189 B2Granted
Screening method for PPAR-γ ligands
AssigneeCity of Hope
InventorBarry Forman
Life of this patent
Estimating the term…
Abstract
The invention relates to a method of identifying nuclear receptor controlled genes in specific tissues. In particular, the method also provides a method of activating PPARγ nuclear receptor controlled target genes in vivo in a tissue-specific manner and screening for PPARγ ligands.
Claims3
A method of screening for compounds that bind to a complex of peroxisome proliferator activated receptor gamma (PPARγ) and PPARγ binding protein (PBP), which comprises:
- (a) incubating a PPARγ-PBP complex with a labeled candidate ligand compound, wherein detectable endogenous PPARγ ligand is not present;
- and
- (b) determining whether said labeled candidate ligand compound has bound to said PPARγ-PBP complex.
Dependencies are inferred from the claim text.