Use of Phyllanthus for treating chronic inflammatory and fibrotic processes
AssigneePhytrix AG
InventorsRolf Gebhardt, Angelika M. Vollmar, Michael P. Manns, Matthias Bahr, Hildebert Wagner, Gayane Hrachia Buniatian
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Abstract
The present invention relates to the use of Phyllanthus for preventing or treating connective tissue proliferations, for maintaining the level of reduced glutathione, for inhibiting lipopolysaccharide (LPS)-induced nitric oxide synthase (NOS) and for inhibiting expression of the cyclooxygenase (COX-2) protein.
Claims37
A method for treating connective tissue proliferation comprising administration of a composition comprising Phyllanthus amarus or a fraction thereof to a patient whereby proliferation of connective tissue in the patient is reduced.
A method of reducing fibrosis of hepatic tissue comprising administering to a patient in need thereof an amount of a composition comprising Phyllanthus amarus or a fraction thereof sufficient to inhibit expression of smooth muscle alpha-actin (SMA), glial fibrillary acidic protein (GFAP), or both.
A method for treating connective tissue proliferation comprising administration of Phyllanthus or a fraction thereof to a patient whereby proliferation of connective tissue in the patient is reduced, wherein said Phyllanthus is an extract of one or more aqueous solvents, nonpolar solvents, alcohol solvents or mixtures thereof, and wherein the one or more solvents comprise ethanol or methanol, wherein the Phyllanthus comprises an ethanol/water extract of the leaves of Phyllanthus amarus and said extract is administered orally.
A method for treating connective tissue proliferation comprising administration of a composition comprising an ethanol/water extract of Phyllanthus niruri or a fraction thereof to a patient whereby proliferation of connective tissue in the patient is reduced.
A method of reducing fibrosis of hepatic tissue comprising administering to a patient in need thereof an amount of a composition comprising an ethanol/water extract of Phyllanthus niruri or a fraction thereof sufficient to inhibit expression of smooth muscle alphaactin (SMA), glial fibrillary acidic protein (GFAP), or both.
Dependencies are inferred from the claim text.